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Using proteomics as a powerful tool to develop a vaccine against Mediterranean visceral leishmaniasis
Sajad Rashidi1, Kurosh Kalantar2, Gholamreza Hatam3
11Department of Parasitology and Mycology, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract:
Visceral leishmaniasis (VL) is a tropical infectious disease, which is called Mediterranean visceral leishmaniasis (MVL) in the Mediterranean area. In spite of many attempts, no effective commercial vaccine exists for MVL. To find new targets for developing antileishmanial vaccines, knowing parasite antigens that provoke the immune system are on demand. Nowadays, proteomics methods are defined as approaches for analysis of protein profiling of different cells. Within this framework, detection of new antigens is becoming more facilitated. In this review, we aimed to introduce possible targets using proteomics so; they could be used as candidates for developing vaccines against MVL. It can shed new light in the near future on the development of promising vaccines for MVL.
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