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Correlation between prostate stem cell antigen gene expression and oral squamous cell carcinoma
Kui Zhao1, Xiaoxu Li1,2, Jiongke Wang1
1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Oncology Letters
|May 31, 2018
Summary
Researchers investigated single nucleotide polymorphisms (SNPs) and their link to oral squamous cell carcinoma (OSCC) susceptibility. A specific SNP, rs2294008 in the prostate stem cell antigen (PSCA) gene, was found to be associated with OSCC risk.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- The causes of oral squamous cell carcinoma (OSCC) are not fully understood.
- Genome-wide association studies (GWAS) have identified numerous single nucleotide polymorphisms (SNPs) linked to various cancers.
Purpose of the Study:
- To identify common SNPs associated with cancer susceptibility.
- To evaluate the involvement of these SNPs in oral squamous cell carcinoma (OSCC).
Main Methods:
- Analysis of a cancer GWAS catalogue to identify susceptible loci.
- A multicentre case-control study involving OSCC patients and controls.
- Functional analysis using reverse transcription-polymerase chain reaction, ELISA, and immunohistochemistry.
Main Results:
- The SNP rs2294008, located in the prostate stem cell antigen (PSCA) gene, was selected for further study.
- The rs2294008 polymorphism showed a significant association with OSCC susceptibility.
- Analysis of genotypes and clinical parameters was performed in 76 OSCC patients.
Conclusions:
- The rs2294008 polymorphism is associated with an increased risk of developing OSCC.
- The prostate stem cell antigen (PSCA) gene may play a role in the development, progression, and prognosis of OSCC.
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