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Updated: Feb 9, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

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Cyclin‑dependent kinase 10 prevents glioma metastasis via modulation of Snail expression

Hui Li1, Yanjie You2, Jianfeng Liu1

  • 1Department of Neurosurgery, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China.

Molecular Medicine Reports
|May 31, 2018
PubMed

Insights

Cyclin-dependent kinase 10 (CDK10) acts as a tumor suppressor in glioma. Downregulation of CDK10 promotes glioma cell metastasis by activating Snail-driven epithelial-mesenchymal transition (EMT), suggesting CDK10 as a therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Cyclin-dependent kinase 10 (CDK10) is implicated as a tumor suppressor in various cancers.
  • The role of CDK10 in glioma biology and regulation remains largely unexplored.

Purpose of the Study:

  • To investigate the biological and regulatory functions of CDK10 in glioma.
  • To determine the association between CDK10 expression and glioma cell proliferation, metastasis, and epithelial-mesenchymal transition (EMT).

Main Methods:

  • Overexpression and knockdown of CDK10 in glioma cell lines.
  • Assessment of cell proliferation and metastasis.
  • Analysis of epithelial-mesenchymal transition (EMT) markers and Snail (SNAI1) expression.

Main Results:

  • CDK10 overexpression inhibited glioma cell proliferation and metastasis.
  • CDK10 knockdown promoted glioma cell proliferation and metastasis.
  • Downregulated CDK10 expression correlated with epithelial-mesenchymal transition (EMT) and increased Snail expression.
  • Silencing Snail expression reversed EMT phenotypes induced by CDK10 knockdown.

Conclusions:

  • CDK10 downregulation promotes glioma metastasis through Snail-driven EMT.
  • CDK10 functions as a tumor suppressor in glioma.
  • CDK10 represents a potential molecular target for glioma therapy.

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