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miR‑205 targets YAP1 and inhibits proliferation and invasion in thyroid cancer cells

Dewei Li1, Qiang Wang2, Ning Li3

  • 1Department of Thyroid Surgery, Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030012, P.R. China.

Molecular Medicine Reports
|May 31, 2018
PubMed

Insights

MicroRNA-205 (miR-205) is reduced in thyroid cancer, inhibiting cell proliferation, migration, and invasion. Targeting Yes-associated protein 1 (YAP1) by miR-205 offers a potential new treatment strategy for thyroid cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNA-205 (miR-205) is implicated in various cancers but its role in thyroid cancer is not well understood.
  • Previous studies show miR-205 downregulation in breast, prostate, and lung cancers, suggesting a tumor-suppressive function.

Purpose of the Study:

  • To investigate the expression and functional role of miR-205 in thyroid cancer.
  • To identify the molecular mechanism underlying miR-205's function in thyroid cancer, including its potential targets.

Main Methods:

  • Quantitative analysis of miR-205 expression in thyroid cancer tissues versus non-cancerous tissues.
  • Establishment of miR-205 knockdown (BHT-101) and overexpression (8505-C) cell models.
  • Assessment of cell proliferation, migration, and invasion assays.
  • Identification and validation of miR-205 target genes using molecular techniques.

Main Results:

  • miR-205 expression was significantly reduced in thyroid cancer tissues compared to normal tissues.
  • Reduced miR-205 levels were associated with increased thyroid cancer cell proliferation, migration, and invasion.
  • Yes-associated protein 1 (YAP1) was identified as a direct target of miR-205, with inverse correlation in tumor tissues.
  • YAP1 depletion partially reversed the effects of miR-205 inhibition on cell growth and invasion.

Conclusions:

  • miR-205 acts as a tumor suppressor in thyroid cancer by targeting YAP1.
  • The miR-205/YAP1 axis represents a potential therapeutic target for thyroid cancer treatment.

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