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Herpetic eye disease study: lessons learned.

Tanja Kalezic1, Mostafa Mazen2, Eric Kuklinski2

  • 1University of Belgrade, Faculty of Medicine, Clinic for Eye Disease, Clinical Center of Serbia, Belgrade, Serbia.

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|May 31, 2018
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Summary
This summary is machine-generated.

Ophthalmic herpes simplex virus (HSV) can cause serious corneal issues. Current guidelines, based on the Herpetic Eye Disease Study (HEDS), remain crucial for treatment, with newer antivirals offering improved options.

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Area of Science:

  • Ophthalmology
  • Virology
  • Corneal Disease

Background:

  • Ophthalmic herpes simplex virus (HSV) infection of the anterior segment leads to significant corneal complications, including scarring, thinning, neovascularization, and vision loss.
  • Understanding and managing HSV keratitis is critical for preserving ocular health and visual function.

Purpose of the Study:

  • To provide an updated review of current guidelines for treating anterior segment disease caused by HSV.
  • To assess the impact of recent therapeutic advancements and surgical procedures on HSV ocular disease management.

Main Methods:

  • Review of findings from the Herpetic Eye Disease Study (HEDS) clinical trials.
  • Evaluation of new topical and antiviral therapies developed post-HEDS.
  • Brief review of vaccine development for recurrent herpetic infections.
  • Analysis of risks associated with new corneal surgical procedures (cross-linking, excimer refractive surgery) for ocular HSV.

Main Results:

  • The Herpetic Eye Disease Study (HEDS) established the foundational standards for HSV ocular therapy, which remain relevant.
  • Newer antiviral medications demonstrate potential for improved compliance, bioavailability, efficacy, dosage, and tolerability.
  • Certain modern corneal surgical techniques may increase the risk of ocular HSV disease recurrence or complications.

Conclusions:

  • HEDS guidelines continue to be the standard for HSV ocular therapy.
  • Emerging antiviral agents offer promising alternatives with enhanced patient-centric benefits.
  • Further research is essential to address HSV latency, reduce recurrence rates, and improve treatment for necrotizing keratitis.