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A Novel Zebrafish (Danio rerio) Assay for Assessing Musk Ambrette-Induced Toxicity

Li Qu1,2, Chaomin Zhao2, Chuanxian Wang2

  • 1School of Public Health, Fudan University, Shanghai, 200032, China.

Bulletin of Environmental Contamination and Toxicology
|May 31, 2018
PubMed

Insights

Musk ambrette, a synthetic fragrance, causes significant toxicity in zebrafish, impacting survival and development. This study reveals its detrimental effects on cardiovascular and vascular systems, highlighting environmental concerns.

Area of Science:

  • Environmental Toxicology
  • Developmental Biology
  • Cardiovascular Research

Background:

  • Musk ambrette is a synthetic fragrance used as a substitute for natural musk.
  • Its persistence and accumulation in organisms raise environmental and health concerns.
  • Understanding its toxicity is crucial for risk assessment.

Purpose of the Study:

  • To investigate the acute toxicity of musk ambrette in zebrafish.
  • To evaluate its effects on early life-stage development and specific organ systems.
  • To determine the lethal concentration (LC50) and identify toxicological endpoints.

Main Methods:

  • Exposure of wild-type and transgenic zebrafish embryos to various musk ambrette concentrations (6-72 hours post-fertilization).
  • Assessment of developmental delays, morphological abnormalities, and mortality.
  • Utilized a zebrafish angiogenesis model to evaluate cardiovascular and vascular toxicity.

Main Results:

  • The LC50 of musk ambrette was determined to be 76.4 µg/mL.
  • Observed dose-dependent toxicities including developmental delays, pericardial edema, and curved body axis.
  • Confirmed cardiotoxicity and vascular development toxicity, evidenced by cardiovascular changes and altered vessel permeability.

Conclusions:

  • Musk ambrette exhibits significant acute toxicity in zebrafish, affecting survival and development.
  • The compound induces specific cardiovascular and vascular abnormalities.
  • These findings underscore the potential environmental risks associated with musk ambrette exposure.
Keywords:
Acute toxicityAngiogenesisCardiotoxicityMusk ambretteNeurotoxicityZebrafish

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