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Differentiating Cerebellar Impact on Thalamic Nuclei.
Simona V Gornati1, Carmen B Schäfer1, Oscar H J Eelkman Rooda2
1Department of Neuroscience, Erasmus Medical Center, 3015 AA Rotterdam, The Netherlands.
Cell Reports
|May 31, 2018
Summary
The cerebellum
Area of Science:
- Neuroscience
- Cell Biology
Background:
- The cerebellum is crucial for motor control and non-motor functions.
- Cerebellar nuclei (CN) connect to the thalamo-cortical network, but details are scarce.
Purpose of the Study:
- To investigate cerebellar input to the ventrolateral (VL), ventromedial (VM), and centrolateral (CL) thalamus.
- To characterize cerebello-thalamic connections.
Main Methods:
- Confocal and electron microscopy to analyze axon terminal morphology.
- In vitro electrophysiological recordings with optogenetic stimulation of CN axons.
Main Results:
- CN axon terminals were denser and larger in the VL thalamus compared to VM or CL.
- Optogenetic CN stimulation caused greater charge transfer and action potential firing in VL neurons versus VM or CL neurons.
Conclusions:
- Cerebellar input significantly impacts different thalamic nuclei differently.
- Cerebellar output may differentially regulate distinct components of the thalamo-cortical network.
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