Related Experiment Video
Updated: Feb 9, 2026

Alternate Immersion in Glucose to Produce Prolonged Hyperglycemia in Zebrafish
Published on: May 5, 2021
Sodium-glucose Cotransporter-2 Induced Diabetic Ketoacidosis with Minimal Hyperglycemia
D Taylor Gammons1, Francis L Counselman1,2
1Eastern Virginia Medical School, Department of Emergency Medicine, Norfolk, Virginia.
Abstract:
The case of a 56-year-old man with a history of type 2 diabetes mellitus who presented to the emergency department in diabetic ketoacidosis (DKA) with only mild hyperglycemia is presented. The patient was taking empagliflozin (Jardiance®), a sodium-glucose cotransporter -2 inhibitor, which has now been recognized as causing this unusual presentation of DKA. Emergency physicians need to be aware of this complication, as the euglycemia/mild hyperglycemia and a history of type 2 diabetes mellitus can make the correct diagnosis of DKA a challenge.
More Related Videos
13:35Acute and Chronic Models of Hyperglycemia in Zebrafish: A Method to Assess the Impact of Hyperglycemia on Neurogenesis and the Biodistribution of Radiolabeled Molecules
Published on: June 26, 2017
10:03A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
Related Concept Videos
Diabetes Mellitus: Type 2 and Gestational
Glucose Homeostasis: Regulation of Blood Glucose
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Regulation of Sodium and Potassium
Sodium Regulation
Sodium ions make up approximately 90% of extracellular cations, with a normal blood plasma concentration of 136–148 mEq/L. A decrease in blood volume and pressure triggers the release of renin from granular cells in the juxtaglomerular complex (JGC), primarily...
Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Roles of Electrolytes: Sodium and Potassium