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Reversible Acute Kidney Injury Associated with Chlorothalonil Ingestion
1University of California Irvine, School of Medicine, UC Irvine Health, UCI Medical Center, Department of Emergency Medicine and Pharmacology, Orange, California.
Clinical Practice and Cases in Emergency Medicine
|June 1, 2018
Summary
This case report details a rare instance of acute kidney injury following chlorothalonil fungicide ingestion. The patient
Area of Science:
- Toxicology
- Nephrology
- Environmental Health
Background:
- Chlorothalonil is a widely used agricultural fungicide.
- Acute toxicity from chlorothalonil ingestion is uncommon.
- Limited data exists on the renal effects of chlorothalonil poisoning.
Observation:
- A 43-year-old male intentionally ingested a chlorothalonil-containing fungicide.
- Upon admission, the patient presented with acute kidney injury (AKI).
- Laboratory tests revealed elevated serum creatinine (2.9 mg/dL), indicative of acute tubular necrosis.
Findings:
- The patient's renal function demonstrated recovery with supportive care and hydration.
- This case represents a rare occurrence of clinically significant renal effects from chlorothalonil toxicity.
- No prior documented cases reported severe kidney damage following chlorothalonil ingestion.
Implications:
- This case highlights the potential nephrotoxic effects of chlorothalonil, even if rare.
- Clinicians should consider chlorothalonil poisoning in patients with unexplained acute kidney injury.
- Further research may be warranted to fully understand the renal toxicity profile of chlorothalonil.
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