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Related Experiment Video

Updated: Feb 9, 2026

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

Published on: July 28, 2020

Apatinib as targeted therapy for sarcoma.

Feng Li^1,2,3,4, Zhichao Liao^1,2,3,4, Chao Zhang^1,2,3,4

¹Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, People's Republic of China.

|June 1, 2018

Summary

Apatinib, a targeted therapy inhibiting vascular endothelial growth factor receptor-2, shows promise for treating sarcomas. This review summarizes preclinical and clinical data on apatinib

Keywords:

apatinib efficacy safety sarcoma targeted therapy

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Area of Science:

Oncology
Cancer Biology
Pharmacology

Background:

Sarcomas are malignant tumors of mesenchymal origin with limited survival improvements from standard treatments.
Pathological angiogenesis is crucial for sarcoma growth and metastasis.
Vascular Endothelial Growth Factor (VEGF) and its receptors (VEGFRs) are key regulators of tumor angiogenesis.

Purpose of the Study:

To review preclinical and clinical data on apatinib for sarcoma treatment.
To highlight apatinib as a novel targeted therapy for angiogenesis.
To assess the potential of apatinib in improving sarcoma patient survival.

Main Methods:

Review of preclinical studies on apatinib's anti-angiogenic and anti-tumor effects.
Analysis of clinical trial data evaluating apatinib in various malignancies, including sarcomas.
Focus on apatinib's selective inhibition of VEGFR-2.

Main Results:

Apatinib demonstrates encouraging anticancer activity across multiple cancer types.
Preclinical and clinical data suggest apatinib's efficacy in sarcoma treatment.
Apatinib's targeted inhibition of VEGFR-2 impacts tumor angiogenesis.

Conclusions:

Apatinib is a promising targeted therapy for sarcomas.
Further investigation into apatinib's role in sarcoma treatment is warranted.
Targeting angiogenesis with apatinib may improve outcomes for sarcoma patients.