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Apatinib as targeted therapy for sarcoma

Feng Li1,2,3,4, Zhichao Liao1,2,3,4, Chao Zhang1,2,3,4

  • 1Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, People's Republic of China.

Oncotarget
|June 1, 2018
PubMed

Insights

Apatinib, a targeted therapy inhibiting vascular endothelial growth factor receptor-2, shows promise for treating sarcomas. This review summarizes preclinical and clinical data on apatinib

Area of Science:

  • Oncology
  • Cancer Biology
  • Pharmacology

Background:

  • Sarcomas are malignant tumors of mesenchymal origin with limited survival improvements from standard treatments.
  • Pathological angiogenesis is crucial for sarcoma growth and metastasis.
  • Vascular Endothelial Growth Factor (VEGF) and its receptors (VEGFRs) are key regulators of tumor angiogenesis.

Purpose of the Study:

  • To review preclinical and clinical data on apatinib for sarcoma treatment.
  • To highlight apatinib as a novel targeted therapy for angiogenesis.
  • To assess the potential of apatinib in improving sarcoma patient survival.

Main Methods:

  • Review of preclinical studies on apatinib's anti-angiogenic and anti-tumor effects.
  • Analysis of clinical trial data evaluating apatinib in various malignancies, including sarcomas.
  • Focus on apatinib's selective inhibition of VEGFR-2.

Main Results:

  • Apatinib demonstrates encouraging anticancer activity across multiple cancer types.
  • Preclinical and clinical data suggest apatinib's efficacy in sarcoma treatment.
  • Apatinib's targeted inhibition of VEGFR-2 impacts tumor angiogenesis.

Conclusions:

  • Apatinib is a promising targeted therapy for sarcomas.
  • Further investigation into apatinib's role in sarcoma treatment is warranted.
  • Targeting angiogenesis with apatinib may improve outcomes for sarcoma patients.
Keywords:
apatinibefficacysafetysarcomatargeted therapy

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