Related Experiment Video
Updated: Feb 9, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
Aberrant Peripheral Immune Function in a Good Syndrome Patient.
Xian Chen1,2, Jie-Xin Zhang1,2, Wen-Wen Shang1,2
1Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Good's syndrome patients exhibit altered peripheral immune cells, including reduced B cells and an inverted CD4+/CD8+ T cell ratio, post-thymoma resection. Immune cell dysfunction and cytokine imbalances necessitate further research into targeted therapies.
Area of Science:
- Immunology
- Clinical Medicine
- Endocrinology
Background:
- Good's syndrome (GS) is characterized by thymoma, immunodeficiency, and potential autoimmune diseases.
- Recurrent infections and chronic diarrhea are common in GS patients, suggesting underlying immune dysregulation.
Related Concept Videos
Functions of the Lymphatic and Immune System
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
What is the Immune System?
Humoral Immune Responses
Nephrotic Syndrome I : Introduction
Acute Coronary Syndrome I: Introduction
Structural Protein Function
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...

