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Related Experiment Video

Updated: Feb 9, 2026

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

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Small Molecules for Psoriasis.

Craig L Leonardi1

  • 1Clinical Professor of Dermatology Saint Louis University Central Dermatology St Louis, Missouri.

Seminars in Cutaneous Medicine and Surgery
|June 1, 2018
PubMed
Summary
This summary is machine-generated.

Acitretin and tofacitinib are oral medications for psoriasis treatment. Both are effective but carry significant safety risks for patients.

Keywords:
Acitretinpsoriasispustular psoriasistofacitinibtoxicity

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Psoriasis treatment involves various therapeutic options.
  • Acitretin is an established oral, non-immunosuppressive drug for psoriasis.
  • Tofacitinib is an oral Janus kinase inhibitor investigated for psoriasis.

Purpose of the Study:

  • To compare the efficacy and safety profiles of acitretin and tofacitinib in psoriasis management.

Main Methods:

  • Review of existing literature on acitretin and tofacitinib for psoriasis.
  • Analysis of clinical trial data regarding efficacy and adverse events.

Main Results:

  • Both acitretin and tofacitinib demonstrate efficacy in treating psoriasis.
  • Each medication presents substantial safety risks that require careful consideration.

Conclusions:

  • Acitretin and tofacitinib are viable treatment options for specific psoriasis patient populations.
  • Risk-benefit assessment is crucial when selecting between these oral therapies.