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Updated: Feb 9, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Esophageal Squamous Cell Carcinoma Metastatic to the Orbit
Katharine S Dempsey1, Norman C Charles1,2, Irina Belinsky1
1Department of Ophthalmology, New York University Langone Medical Center.
Abstract:
A 74-year-old man presenting with proptosis and orbital inflammation was found on magnetic resonance imaging to have a unilateral intraconal mass. Biopsy revealed a high-grade malignant tumor that was interpreted as squamous cell carcinoma. Positron emission tomography-computed tomography imaging subsequently identified a primary lesion in the esophagus. Esophageal squamous cell carcinoma is a rare cause of orbital metastasis, with only 4 previously reported cases. The authors discuss an approach to orbital malignancies of obscure origin.
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