Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The Human Egg's Zona Pellucida.

Satish K Gupta1

  • 1Reproductive Cell Biology Laboratory, National Institute of Immunology, New Delhi, India.

Current Topics in Developmental Biology
|June 2, 2018
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gender and Refractive Error Stratified Ocular Biometry Percentile Curves in Indian School Children.

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)·2026
Same author

Contribution and Compensation Effects of Refracting Components to Ocular Aberrations in Keratoconus.

Investigative ophthalmology & visual science·2025
Same author

Silicon mediated heavy metal stress amelioration in fruit crops.

Heliyon·2024
Same author

Is There Any Association between Nutrition and Myopia? A Systematic Review.

Optometry and vision science : official publication of the American Academy of Optometry·2023
Same author

Myopia progression risk assessment score (MPRAS): a promising new tool for risk stratification.

Scientific reports·2023
Same author

Contraceptive efficacy of recombinant porcine zona proteins and fusion protein encompassing canine ZP3 fragment and GnRH in female beagle dogs.

American journal of reproductive immunology (New York, N.Y. : 1989)·2022
Same journal

Building a resilient ovarian reserve: Early soma-oocyte interactions.

Current topics in developmental biology·2026
Same journal

Role of macrophages in testis function.

Current topics in developmental biology·2026
Same journal

Role of retinoic acid in meiosis.

Current topics in developmental biology·2026
Same journal

Impact of cancer immunotherapies on oocyte health and ovarian function.

Current topics in developmental biology·2026
Same journal

The ovarian stroma as a key regulator of follicular development and gamete quality across the reproductive lifespan.

Current topics in developmental biology·2026
Same journal

Intercellular cyclic nucleotide dynamics mediate oocyte meiosis in mammalian preovulatory follicles.

Current topics in developmental biology·2026
See all related articles

Human zona pellucida (ZP) glycoproteins ZP1, ZP2, ZP3, and ZP4 are crucial for sperm binding and the acrosome reaction. Their glycosylation and interactions with sperm are key to fertilization and potential infertility causes.

Area of Science:

  • Reproductive Biology
  • Glycobiology
  • Molecular Reproduction

Background:

  • The human zona pellucida (ZP) is a glycoprotein matrix essential for fertilization.
  • It comprises ZP1, ZP2, ZP3, and ZP4, sharing common structural domains.
  • These proteins play critical roles in sperm-egg interactions.

Purpose of the Study:

  • To review the structural and functional characteristics of human ZP glycoproteins.
  • To explore their binding interactions with spermatozoa.
  • To discuss their role in inducing the acrosome reaction and potential links to infertility.

Main Methods:

  • Review of existing literature on human ZP glycoproteins.
  • Analysis of studies using recombinant/native zona proteins to assess sperm binding.
Keywords:
Acrosome reactionFertilizationHuman zona pellucida glycoproteinsInfertilityZP autoantibodiesZP1ZP2ZP3ZP4Zona-sperm binding

Related Experiment Videos

  • Examination of data from transgenic mice studies and investigations into signaling pathways.

    • Main Results:

    • ZP1, ZP3, and ZP4 bind to capacitated sperm heads; ZP2 binds to acrosome-reacted sperm.
    • Human ZP2's N-terminal region is important for sperm-egg binding.
    • ZP1, ZP3, and ZP4 induce dose-dependent acrosome reactions, with glycosylation being essential.
    • Distinct signaling pathways are activated by ZP3 versus ZP1/ZP4.

    Conclusions:

    • Multiple human ZP glycoproteins contribute to inducing the acrosome reaction.
    • Glycosylation, including N-linked glycosylation and sialyl-Lewisx, is vital for this process.
    • Further research is needed to confirm the role of ZP protein mutations and autoantibodies in female infertility.