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Linagliptin safety profile: A systematic review
Gabrielle Kéfrem Alves Gomes1, Aline Istéfane de Camargos Ramos1, Camila Tavares de Sousa1
1Universidade Federal de São João del-Rei, Campus Centro Oeste Dona Lindu, Rua Sebastião Gonçalves Coelho, 400, Bairro Chanadour, CEP 35501-296, Divinópolis, MG, Brazil; Grupo de Pesquisa em Epidemiologia e Avaliação de Novas Tecnologias em Saúde, GPEANTS, UFSJ/CNPq, Brazil.
Objective:
To describe the safety profile of linagliptin.
Methodology:
Systematic review using PubMed/MEDLINE, BVS and Web of Science. The search strategy "Linagliptin" AND "safety" was used. The inclusion criteria were clinical trials with a control group composed of conventional DM2 pharmacotherapy.
Results:
We identified 16 studies, and the most frequent adverse events (AEs) were nasopharyngitis with linagliptin at 5 and 10mg in monotherapy (31.6% and 29.6%, respectively) and gastrointestinal events (>10.0%) with linagliptin in combination. Of the AEs, 14.9 (±3.1)% were associated with the use of linagliptin in monotherapy, and 17.6 (±6.0)% in combination. The linagliptin AEs have a varied occurrence and frequency, ranging from mild to moderate intensity.
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