Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Mitotic Spindle02:27

The Mitotic Spindle

8.1K
The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where the now individual chromosomes are distributed to two daughter cell nuclei.
The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures...
8.1K
Spindle Assembly02:50

Spindle Assembly

4.3K
Spindle assembly occurs through three, often coexisting, pathways – the centrosome-mediated pathway, the chromatin-mediated pathway, and the microtubule-mediated pathway – collectively contributing to form a robust spindle apparatus.
In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a...
4.3K
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

956
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
956
The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

3.9K
The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
3.9K
pH Scale02:41

pH Scale

80.2K
Hydronium and hydroxide ions are present both in pure water and in all aqueous solutions, and their concentrations are inversely proportional as determined by the ion product of water (Kw). The concentrations of these ions in a solution are often critical determinants of the solution’s properties and the chemical behaviors of its other solutes. Two different solutions can differ in their hydronium or hydroxide ion concentrations by a million, billion, or even trillion times. A common means of...
80.2K
Stages of Sleep01:22

Stages of Sleep

1.5K
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural features of endogenous polyphenols in modulating oxidative stability of tiger nut (Cyperus esculentus L.) oil: Insights from Rancimat and density functional theory.

Food chemistry·2026
Same author

Delayed Arousal Response to Sleep Apnea Encodes Mortality.

medRxiv : the preprint server for health sciences·2026
Same author

SERPINE1 drives ferroptosis in acute respiratory distress syndrome by disrupting mitochondrial NAD<sup>+</sup> homeostasis and suppressing Sirt3 activity.

Redox biology·2026
Same author

Hootation: A GUI and API library for ontology validation and verbalization.

Proceedings. IEEE International Conference on Semantic Computing·2026
Same author

Protocol for detecting genome-wide introgressed genes and evaluating their functional legacy.

STAR protocols·2026
Same author

A layered standards framework for integrating single-cell and spatial omics data into brain cell atlases.

bioRxiv : the preprint server for biology·2026
Same journal

Sensitivity Analyses of a Scoring System for a Contraception Decision Aid.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same journal

Improving electronic health record processing of large language models via retrieval-augmented generation: A case study on dietary supplements.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same journal

Developing a User-Centered Mobile Application Prototype: Bridging Lower-Limb Fracture Care from Skilled Nursing Facility and Back to the Community.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same journal

KERAP: A Knowledge-Enhanced Reasoning Approach for Accurate Zero-shot Diagnosis Prediction Using Multi-agent LLMs.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same journal

Automating Adjudication of Cardiovascular Events Using Large Language Models.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
Same journal

Predictive Factors and State-Level Barriers to Postpartum Birth Control Usage in the United States: Insights from PRAMS Phase 8.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2026
See all related articles

Related Experiment Video

Updated: Feb 9, 2026

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
07:51

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

Published on: September 26, 2018

8.1K

SpindleSphere: A Web-based Platform for Large-scale Sleep Spindle Analysis and Visualization.

Xiaojin Li1,2, Licong Cui1,3, Shiqiang Tao1

  • 1Institute for Biomedical Informatics, University of Kentucky, Lexington, KY.

AMIA ... Annual Symposium Proceedings. AMIA Symposium
|June 2, 2018
PubMed
Summary
This summary is machine-generated.

We developed SpindleSphere, a novel platform for managing and visualizing sleep spindle data. This tool aids neurological disease research by standardizing polysomnography data processing and analysis.

More Related Videos

Polygraphic Recording Procedure for Measuring Sleep in Mice
08:45

Polygraphic Recording Procedure for Measuring Sleep in Mice

Published on: January 25, 2016

25.3K
Quantitative Measurement of the Immune Response and Sleep in Drosophila
12:16

Quantitative Measurement of the Immune Response and Sleep in Drosophila

Published on: December 4, 2012

16.0K

Related Experiment Videos

Last Updated: Feb 9, 2026

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
07:51

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

Published on: September 26, 2018

8.1K
Polygraphic Recording Procedure for Measuring Sleep in Mice
08:45

Polygraphic Recording Procedure for Measuring Sleep in Mice

Published on: January 25, 2016

25.3K
Quantitative Measurement of the Immune Response and Sleep in Drosophila
12:16

Quantitative Measurement of the Immune Response and Sleep in Drosophila

Published on: December 4, 2012

16.0K

Area of Science:

  • Neuroscience
  • Computational Biology
  • Sleep Medicine

Background:

  • Sleep spindles, characteristic of stage 2 non-REM sleep, hold genetic information relevant to neurological diseases.
  • Current research is hindered by the absence of a unified data processing pipeline and web-based platform for large-scale spindle data management and visualization.

Purpose of the Study:

  • To introduce SpindleSphere, a scalable, integrated data management and visualization platform designed to address the challenges in sleep spindle research.
  • To facilitate efficient analysis and clinical research leveraging sleep spindle characteristics.

Main Methods:

  • Development of SpindleSphere, featuring standardized metadata-based querying of polysomnography (PSG) data.
  • Implementation of event-specific signal exporting, interactive waveform visualization, and multi-scale spindle rendering.
  • Utilizing a parallel MapReduce algorithm for efficient detection and analysis of sleep spindle segments.

Main Results:

  • SpindleSphere enables real-time, multi-modal signal visualization from the National Sleep Research Resource (NSRR) for detailed spindle characterization.
  • Preliminary evaluation demonstrated the platform's capability on a substantial dataset (130 GB PSG data from 300 subjects).
  • The platform supports standardized data querying and event-specific signal analysis.

Conclusions:

  • SpindleSphere offers a robust solution for managing and visualizing sleep spindle data at scale, crucial for advancing neurological disease research.
  • The platform enhances the accessibility and analytical power for researchers working with polysomnography data.
  • SpindleSphere represents a significant step forward in leveraging sleep spindle information for clinical and genetic studies.