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Updated: Feb 9, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Relapse Rate and MRI Activity in Young Adult Patients With Multiple Sclerosis: A Post Hoc Analysis of Phase 3

Jutta Gärtner1, Tanuja Chitnis2, Angelo Ghezzi3

  • 1Department of Pediatrics and Adolescent Medicine, German Centre for Multiple Sclerosis in Childhood and Adolescence, University Medical Center Göttingen, Germany.

Multiple Sclerosis Journal - Experimental, Translational and Clinical
|June 2, 2018
PubMed
Abstract

Insights

Young adults with multiple sclerosis (MS) experience higher disease activity. Fingolimod treatment significantly reduced relapses and new lesions, showing greater benefits in younger patients compared to the general MS population.

Area of Science:

  • Neurology
  • Immunology
  • Clinical Trials

Background:

  • Multiple sclerosis (MS) exhibits distinct disease activity patterns in young adults compared to the general adult population.
  • Understanding these differences is crucial for effective treatment strategies.

Purpose of the Study:

  • To assess the efficacy of fingolimod 0.5 mg in managing disease activity in young adults with MS.
  • Evaluate treatment effects across different age strata within the young adult demographic.

Main Methods:

  • Analysis of data from three randomized, double-blind Phase 3 trials.
  • Comparison of annualized relapse rate (ARR), new/enlarging T2 lesions (neT2), and no evidence of disease activity (NEDA-3) between age groups and treatment arms.
  • Statistical modeling using negative binomial and logistic regression, with age as a covariate.

Main Results:

  • Younger patients exhibited higher ARR, which was significantly reduced by fingolimod.
  • Fingolimod demonstrated a significant reduction in neT2 lesions across most age groups compared to placebo or interferon beta-1a (IFN β-1a).
  • Fingolimod treatment led to higher rates of NEDA-3 achievement, with the most pronounced benefits observed in the youngest patients.

Conclusions:

  • Young adults with MS present with elevated disease activity.
  • Fingolimod treatment offers significant benefits for young adults with MS, potentially exceeding those seen in the overall adult population.
Keywords:
Agedisabilityfingolimodmultiple sclerosisrelapse ratesyoung adult

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