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Updated: Feb 9, 2026
Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
Impact of ST-segment resolution on clinical outcome in patients with ST-segment elevation myocardial infarction and
Ahmed Bendary1, Wael Tawfeek1, Mohamed Mahros1
1Cardiology Department, Benha Faculty of Medicine, Benha University, Benha, Egypt.
Background:
Patients with successful reperfusion and preserved left ventricular ejection fraction (LVEF) after ST-segment myocardial infarction (STEMI)have always been thought to have low risk for adverse events. Great interest is focused on finding simple, noninvasive tools to refine risk stratification among them.
Objectives:
We hypothesized that degree of ST-segment resolution (STR) after STEMI can identify high-risk group among patients with LVEF ≥ 50% following STEMI.
Methods:
During the period from January to July 2017, patients with successful reperfusion of STEMI and LVEF ≥ 50% were prospectively included. Patients were divided into two groups based on the percent of ST segment resolution using single lead STR method; group I (complete STR ≥ 70%) and group II (partial STR 50%-70%). The endpoint was a composite of cardiovascular mortality, re-hospitalization for heart failure and urgent revascularization at 30-day.
Results:
After exclusion, 110 patients were left for final analysis. No significant differences in all baseline characteristics were found between both groups. The primary endpoint occurred in seven patients (12.7%) of group I versus 17 patients (30.9%) of group II (Relative risk = 2.43, 95%CI = 1.1-5.4, p = 0.021) driven by a significant reduction in rates of re-hospitalization due to heart failure. A multivariate logistic regression analysis showed incomplete STR to be a significant independent predictor for 30-dayMACEs (OR 3.25, 95% CI1.2-8.83, p = 0.02) even after adjustment for location of infarction.
Conclusion:
Complete STR predicts 30-day outcome in patients with preserved LVEF following successful reperfusion of STEMI.
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