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Pharmacokinetic interactions between digoxin and other drugs
Journal of the American College of Cardiology
|May 1, 1985
Summary
Digoxin drug interactions are critical due to its narrow therapeutic index. Many medications can alter digoxin levels, requiring careful physician monitoring when treatment regimens change.
Area of Science:
- Pharmacology
- Clinical Pharmacy
Background:
- Digoxin is a crucial medication with a narrow therapeutic index.
- Understanding its drug interactions is vital for patient safety.
Purpose of the Study:
- To review significant drug interactions affecting digoxin bioavailability and pharmacokinetics.
- To highlight the clinical implications of these interactions for healthcare providers.
Main Methods:
- Literature review of studies on digoxin drug interactions.
- Analysis of mechanisms by which various drugs affect digoxin levels.
Main Results:
- Several drug classes can decrease digoxin bioavailability (e.g., cholestyramine, antacids).
- Antibiotics can increase digoxin bioavailability by altering gut flora.
- Antiarrhythmics (quinidine, amiodarone) and calcium channel blockers (verapamil) increase digoxin levels.
- Diuretics and indomethacin can alter digoxin pharmacokinetics, especially in specific populations.
Conclusions:
- Numerous medications interact with digoxin, impacting its efficacy and safety.
- Constant vigilance is necessary when adjusting drug regimens containing digoxin.