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Related Experiment Video

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An Aptamer-based Sensor for Unchelated GadoliniumIII
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Does renal function affect gadolinium deposition in the brain?

Feride Kural Rahatli1, Fuldem Yildirim Donmez1, Seda Kibaroglu2

  • 1Baskent University, Faculty of Medicine, Department of Radiology, Ankara, Turkey.

European Journal of Radiology
|June 3, 2018
PubMed
Summary

Patients on chronic hemodialysis show increased gadolinium deposition in the brain compared to those with normal renal function. This indicates renal function impacts gadolinium-based contrast agent accumulation.

Keywords:
Brain MRIDentate nucleusGadolinium based contrast agentGlobus pallidusHemodialysis

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Area of Science:

  • Neuroradiology
  • Nephrology
  • Radiology

Background:

  • Gadolinium-based contrast agents (GBCAs) are widely used in Magnetic Resonance Imaging (MRI).
  • Concerns exist regarding gadolinium deposition in the brain, particularly with repeated administration.
  • The impact of renal function on gadolinium deposition is not fully understood.

Purpose of the Study:

  • To compare T1 signal intensity ratios in specific brain regions (dentate nucleus and globus pallidus) between patients on chronic hemodialysis and those with normal renal function.
  • To investigate whether renal function influences the deposition of gadolinium in the brain following administration of linear GBCAs.

Main Methods:

  • Retrospective evaluation of 78 contrast-enhanced brain MRIs from two groups: 13 patients on chronic hemodialysis and 13 patients with normal renal function.
  • Measurement of T1 signal intensity ratios: dentate nucleus to cerebellar white matter (DN/cerebellum), dentate nucleus to pons (DN/pons), and globus pallidus to thalamus (GP/thalamus).
  • Ratios were assessed from unenhanced axial T1-weighted images.

Main Results:

  • Statistically significant increases in DN/pons, DN/cerebellum, and GP/thalamus signal intensity ratios were observed between the first and last MRIs in the hemodialysis group (p=0.001).
  • No significant changes in these ratios were found in the control group (p>0.05).
  • The increase in signal intensity in the dentate nucleus and globus pallidus was significantly higher in the hemodialysis group compared to the control group (p<0.05).

Conclusions:

  • Patients undergoing chronic hemodialysis exhibit significantly higher signal intensity increases in the dentate nucleus and globus pallidus compared to individuals with normal renal function.
  • Renal function plays a crucial role in determining the rate and extent of gadolinium deposition in the brain after administration of linear GBCAs.