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Case Report: Osimertinib achieved remarkable and sustained disease control in an advanced non-small-cell lung cancer

Minglei Yang1, Xiaoling Tong2, Xiang Xu1

  • 1Department of Cardiothoracic Surgery, Ningbo No. 2 Hospital, Ningbo, Zhejiang, 315012, China.

Lung Cancer (Amsterdam, Netherlands)
|June 3, 2018
PubMed

Insights

Rare EGFR exon 20 mutations in non-small-cell lung cancer (NSCLC) can be treated with third-generation tyrosine kinase inhibitors (TKIs). A patient with a complex EGFR mutation showed sustained disease control with osimertinib, offering insights for future treatments.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Missense mutations in EGFR exon 20 are uncommon in NSCLC.
  • These mutations often confer resistance to first-generation EGFR TKIs.
  • The efficacy of third-generation TKIs against these rare mutations remains largely unknown.
Keywords:
Complex mutationsEGFRNon-small cell lung cancerOsimertinibTyrosine kinase inhibitors

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