Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vitamins01:30

Vitamins

2.5K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.5K
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

8.0K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
8.0K
Mineral, Vitamin and Water Absorption01:27

Mineral, Vitamin and Water Absorption

1.6K
Electrolytes are essential minerals and ions primarily obtained from the diet and absorbed through the gastrointestinal tract. Most electrolytes are absorbed in the small intestine. While the absorption of iron and calcium primarily occurs in the duodenum, calcium is also absorbed in the jejunum and ileum. In these regions, passive diffusion contributes to its absorption alongside active transport mechanisms in the duodenum. These ions can exit the enterocytes through specialized active...
1.6K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

5.6K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.6K
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

2.5K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
2.5K
Testes: Histology01:27

Testes: Histology

3.1K
A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
The spermatogenic cells, responsible for producing sperm, are...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reviving Vavilov's vision: The tragedy of biodiversity governance and principles for reform.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

A Transient Phenolate Enables Relaxation of Z-Tetra-ortho-fluoroazobenzene to the Stable State in Seconds.

Angewandte Chemie (International ed. in English)·2025
Same author

Polypharmacy in Older Patients.

British journal of hospital medicine (London, England : 2005)·2024
Same author

A cautious approach to subsidies for environmental sustainability.

Science (New York, N.Y.)·2024
Same author

Assessment of ethanol and nicotine interactions using a reinforcer demand modeling with grouped and individual levels of analyses in a long-access self-administration model using male rats.

Frontiers in behavioral neuroscience·2023
Same author

CATALYST: challenging antibiotic allergy status.

The Journal of antimicrobial chemotherapy·2023
Same journal

Resident doctor workforce wellbeing worldwide: lessons between the United Kingdom and Australia.

Clinical medicine (London, England)·2026
Same journal

Premature ventricular complexes.

Clinical medicine (London, England)·2026
Same journal

Heart failure with preserved ejection fraction (HFpEF): diagnosis and management for the general physician.

Clinical medicine (London, England)·2026
Same journal

Trends and Widening Inequities in Cardiovascular-Kidney-Metabolic Involvement in Cardiovascular Mortality: A National Spatiotemporal Analysis, 2014-2023.

Clinical medicine (London, England)·2026
Same journal

Educating current and future healthcare professionals on evidence-based sustainable medicine.

Clinical medicine (London, England)·2026
Same journal

UK Foundation Programme training needs a national minimum standard for advanced life support.

Clinical medicine (London, England)·2026
See all related articles

Related Experiment Video

Updated: Feb 9, 2026

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
12:48

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

66.8K

Vitamin D: too much testing and treating?

Henry J Woodford1, Scott Barrett2, Stewart Pattman3

  • 1North Tyneside General Hospital, Northumbria Healthcare NHS Foundation Trust, North Shields, UK henry.woodford@nhct.nhs.uk.

Clinical Medicine (London, England)
|June 3, 2018
PubMed
Summary
This summary is machine-generated.

Clinical uncertainty surrounds serum 25-Hydroxy vitamin D (25[OH]D) testing. A retrospective analysis revealed that a significant majority of tests, potentially 70-77%, may be inappropriate, suggesting a need for more rational testing strategies to reduce healthcare costs.

Keywords:
Vitamin Dcolecalciferoltestingtreatment

More Related Videos

Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling
05:03

Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling

Published on: December 27, 2024

1.7K
Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions
08:18

Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions

Published on: October 4, 2024

1.5K

Related Experiment Videos

Last Updated: Feb 9, 2026

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
12:48

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

66.8K
Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling
05:03

Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling

Published on: December 27, 2024

1.7K
Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions
08:18

Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions

Published on: October 4, 2024

1.5K

Area of Science:

  • Endocrinology
  • Clinical Chemistry
  • Public Health

Background:

  • Clinical uncertainty exists regarding the appropriate testing of serum 25-Hydroxy vitamin D (25[OH]D) and the use of high-dose supplementation.
  • A notable increase in 25[OH]D testing and high-dose supplementation has been observed in recent years.

Purpose of the Study:

  • To analyze the appropriateness of serum 25[OH]D test requests.
  • To evaluate the patterns of 25[OH]D testing and identify areas for improved clinical practice.

Main Methods:

  • Retrospective analysis of 17,405 serum 25[OH]D test requests from January to October 2017.
  • Classification of test requests into 'appropriate', 'inappropriate', and 'uncertain' categories based on expert opinion.
  • Analysis of average 25[OH]D concentrations across different age groups.

Main Results:

  • The overall average 25[OH]D concentration was 57.5 nmol/L, with higher rates of <25 nmol/L in patients over 75.
  • Between 70.4% and 77.5% of tests were deemed potentially inappropriate, with tiredness/fatigue cited in 22.4% of requests.
  • Significant variation in test appropriateness was noted, particularly concerning 'uncertain' categories like falls and osteoporosis.

Conclusions:

  • A substantial proportion of serum 25[OH]D testing may be inappropriate, indicating a need for revised testing guidelines.
  • Implementing a more rational approach to 25[OH]D testing and treatment could lead to significant cost savings for healthcare systems and patients.
  • Further research into optimizing vitamin D testing protocols is warranted to ensure efficient and effective patient care.