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The ITS2 Database
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Allele Frequency Net Database.

Faviel F Gonzalez-Galarza1, Antony McCabe2, Eduardo J Melo Dos Santos3

  • 1Department of Molecular Immunobiology, Faculty of Medicine, Centre for Biomedical Research, Autonomous University of Coahuila, Torreón, Coahuila, Mexico. faviel.gonzalez@uadec.edu.mx.

Methods in Molecular Biology (Clifton, N.J.)
|June 3, 2018
PubMed
Summary
This summary is machine-generated.

The Allele Frequency Net Database (AFND) provides immune-related gene and allele frequencies for over 1505 human populations. This valuable resource aids research in immunology, genetics, and population studies.

Keywords:
FrequenciesHLAImmunogeneticsPolymorphismsPopulation genetics

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Area of Science:

  • Immunology
  • Population Genetics
  • Bioinformatics

Background:

  • The Allele Frequency Net Database (AFND) is a comprehensive online repository.
  • It houses data on immune-related gene and allele frequencies across diverse human populations worldwide.
  • The database includes extensive information on the human leukocyte antigen (HLA) system.

Purpose of the Study:

  • To present commonly used search functionalities within the AFND.
  • To highlight recent advancements and developments in the AFND platform.
  • To underscore the utility of AFND in various scientific disciplines.

Main Methods:

  • Data compilation from numerous global populations.
  • Inclusion of genetic data from polymorphic regions, notably HLA.
  • Development and refinement of web-based searching mechanisms.

Main Results:

  • AFND currently contains data from 1505 populations, encompassing over ten million individuals.
  • The database facilitates research in histocompatibility, immunology, epidemiology, pharmacogenetics, and population genetics.
  • Recent updates enhance the accessibility and utility of AFND for researchers.

Conclusions:

  • AFND serves as a critical resource for understanding human genetic diversity in immune-related genes.
  • The database's search features and ongoing developments support a wide range of scientific investigations.
  • Continued expansion and refinement of AFND will further benefit the scientific community.