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Updated: Feb 9, 2026

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Skin drug permeability and safety through a vibrating solid micro-needle system.

Ting-Ting Liu1, Kai Chen2, Qiao Wang3

  • 1School of Mechanical Engineering, Hangzhou Dianzi University, Zhejiang, 310018, Hangzhou, China.

Drug Delivery and Translational Research
|June 3, 2018
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Summary

Vibrating micro-needles enhance transdermal drug delivery for hydrophilic medications. Increased vibration frequency boosts drug permeation and effectiveness, offering a safe and efficient method for drug administration.

Keywords:
Drug deliveryMicro-needlePermeabilityVibration

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Area of Science:

  • Biomedical Engineering
  • Pharmaceutics
  • Dermatology

Background:

  • Transdermal drug delivery offers advantages over conventional routes.
  • Physical methods like micro-needles and sonophoresis enhance skin permeation.
  • Optimizing micro-needle design and application is crucial for effective drug delivery.

Purpose of the Study:

  • To investigate the efficacy and safety of a vibrating solid micro-needle system for transdermal drug delivery.
  • To evaluate the impact of vibration frequency on skin permeation and drug absorption.
  • To assess the creation of micro-conduits and skin integrity post-treatment.

Main Methods:

  • Fabrication and SEM analysis of vibrating solid micro-needles.
  • Evan's blue staining and histological evaluation for skin morphology.
  • Trans-epidermal water loss (TEWL) and infection studies on rat skin.
  • In vivo insulin delivery and tetramethylpyrazine hydrochloride (TMPH) permeation studies.

Main Results:

  • Vibrating micro-needles created visible micro-conduits and enhanced Evan's blue diffusion.
  • TEWL increased with vibration frequency; minor white blood cell increase observed.
  • Significantly enhanced transdermal delivery of insulin and TMPH, correlated with vibration frequency.
  • Micro-needles maintained structural integrity post-application.

Conclusions:

  • Vibrating solid micro-needles are effective and safe for transdermal administration of hydrophilic drugs.
  • Enhanced drug permeation and delivery efficacy are achieved with increased vibration frequency.
  • This technology presents a promising approach for improving transdermal drug delivery systems.