Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diencephalon: Hypothalamus and Coordination01:23

Diencephalon: Hypothalamus and Coordination

4.3K
The hypothalamus is a small yet highly complex and essential brain region that plays a crucial role in regulating various bodily functions. Anatomically, it is located at the base of the brain, just above the brainstem and below the thalamus, forming part of the limbic system.
The hypothalamus interacts with other brain regions, including the pituitary gland, through a direct physical connection called the hypothalamic-pituitary axis. The hypothalamus receives somatic and visceral inputs and...
4.3K
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

66.4K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
66.4K
Hormonal Regulation01:33

Hormonal Regulation

36.1K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
36.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identifying Novel Estrogenic Mitochondrial Targets in Hypothalamic Proopiomelanocortin Neurons by Chemoproteomics.

bioRxiv : the preprint server for biology·2026
Same author

Blockade of FGFR1 Trafficking to the Cell Surface Results in the Partial Mistargeting of the Receptor to Peroxisomes.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Ionic Liquid-Laden Mesoporous Silica for Ultrafast Gold Recovery Via Nanoconfined Interfacial Anion Exchange.

The journal of physical chemistry letters·2026
Same author

The role of leptin in reproductive dysfunction in patients with varicocele: a systematic review and meta-analysis.

Frontiers in urology·2026
Same author

Regulation of Pore Evolution via Progressive Electroporation Enhanced Intracellular Molecule Transport.

Research (Washington, D.C.)·2026
Same author

GGAs: Regulation of Multiple Sorting Pathways and Potential Association With Human Diseases.

Journal of cellular and molecular medicine·2026
Same journal

Neuroendocrine mechanisms of stress-induced KNDy-GnRH pulse generator suppression: Linking HPA-axis activation to female reproductive dysfunction.

Frontiers in neuroendocrinology·2026
Same journal

Aging-related autonomic nervous system imbalance and adrenergic regulation of immunity: Implications for inflammaging, autoimmunity, and long COVID.

Frontiers in neuroendocrinology·2026
Same journal

Neuroactive steroids as targets of micro- and nano-plastics: Putative impact on brain function and disease.

Frontiers in neuroendocrinology·2026
Same journal

Systems neuroendocrinology in ME/CFS and long COVID: a chronobiological framework for hormone-based research.

Frontiers in neuroendocrinology·2026
Same journal

N-methyl-d-aspartate receptor subunits interacting with regulators mediate neuropathic pain: from mechanisms to therapy.

Frontiers in neuroendocrinology·2026
Same journal

Mechanisms of photoperiodic polyphenism in vertebrates.

Frontiers in neuroendocrinology·2026
See all related articles

Related Experiment Video

Updated: Feb 9, 2026

Genetic Manipulation of the Mouse Developing Hypothalamus through In utero Electroporation
11:48

Genetic Manipulation of the Mouse Developing Hypothalamus through In utero Electroporation

Published on: July 24, 2013

16.5K

TRPCing around the hypothalamus.

Martin J Kelly1, Jian Qiu2, Oline K Rønnekleiv1

  • 1Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, OR, USA; Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA.

Frontiers in Neuroendocrinology
|June 4, 2018
PubMed
Summary
This summary is machine-generated.

Transient Receptor Potential Channels (TRPC) are crucial in hypothalamic neurons for regulating functions like temperature and energy balance. These channels are activated by neurotransmitters and hormones, making them key targets for maintaining homeostasis.

Keywords:
17β-estradiolGnRHInsulinKisspeptinLeptinNeurokinin BOrexinPOMCTRPC channels

More Related Videos

Cortex-, Hippocampus-, Thalamus-, Hypothalamus-, Lateral Septal Nucleus- and Striatum-specific In Utero Electroporation in the C57BL/6 Mouse
06:00

Cortex-, Hippocampus-, Thalamus-, Hypothalamus-, Lateral Septal Nucleus- and Striatum-specific In Utero Electroporation in the C57BL/6 Mouse

Published on: January 18, 2016

29.0K
Membrane Potential Dye Imaging of Ventromedial Hypothalamus Neurons From Adult Mice to Study Glucose Sensing
11:10

Membrane Potential Dye Imaging of Ventromedial Hypothalamus Neurons From Adult Mice to Study Glucose Sensing

Published on: November 27, 2013

14.3K

Related Experiment Videos

Last Updated: Feb 9, 2026

Genetic Manipulation of the Mouse Developing Hypothalamus through In utero Electroporation
11:48

Genetic Manipulation of the Mouse Developing Hypothalamus through In utero Electroporation

Published on: July 24, 2013

16.5K
Cortex-, Hippocampus-, Thalamus-, Hypothalamus-, Lateral Septal Nucleus- and Striatum-specific In Utero Electroporation in the C57BL/6 Mouse
06:00

Cortex-, Hippocampus-, Thalamus-, Hypothalamus-, Lateral Septal Nucleus- and Striatum-specific In Utero Electroporation in the C57BL/6 Mouse

Published on: January 18, 2016

29.0K
Membrane Potential Dye Imaging of Ventromedial Hypothalamus Neurons From Adult Mice to Study Glucose Sensing
11:10

Membrane Potential Dye Imaging of Ventromedial Hypothalamus Neurons From Adult Mice to Study Glucose Sensing

Published on: November 27, 2013

14.3K

Area of Science:

  • Neuroscience
  • Physiology

Background:

  • Canonical Transient Receptor Potential (TRPC) channels are expressed in hypothalamic neurons, excluding TRPC2.
  • TRPC channels are implicated in various homeostatic functions, including reproduction, temperature regulation, arousal, and energy balance.

Purpose of the Study:

  • To review the role of TRPC channels in the hypothalamus.
  • To highlight TRPC channels as key targets for neurotransmitters and circulating hormones in hypothalamic functions.

Main Methods:

  • Literature review of studies on TRPC channels in the hypothalamus.
  • Analysis of the coupling mechanisms between G protein-coupled receptors (GPCRs), growth factor/cytokine receptors, and TRPC channel activation.
  • Examination of the role of hormones like insulin and leptin in TRPC channel activation.

Main Results:

  • In the hypothalamus, TRPC channels are activated by various receptors, including amine and peptidergic GPCRs, and growth factor/cytokine receptors.
  • Circulating hormones such as insulin and leptin activate TRPC channels in POMC neurons.
  • The expression of TRPC channels in postsynaptic neurons regulates the effects of neurotransmitters and hormones in different physiological states.

Conclusions:

  • TRPC channels are essential mediators of hypothalamic functions.
  • TRPC channels serve as critical targets for both neurotransmitters and circulating hormones to control vital homeostatic processes.