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An Observational Epidemiological Study of Exercise-induced Rhabdomyolysis Causing Acute Kidney Injury: A
W L Jabur1, P Nasa2, K A Mohammed3
1Department of Nephrology, NMC Specialty Hospital, Dubai, UAE.
Indian Journal of Nephrology
|June 5, 2018
Summary
Exercise-induced rhabdomyolysis can lead to acute kidney injury (AKI). Patients with AKI often present with systemic symptoms, dehydration, and elevated creatinine kinase, requiring renal replacement therapy.
Area of Science:
- Nephrology
- Sports Medicine
- Internal Medicine
Background:
- Exercise-induced rhabdomyolysis (EIR) is an uncommon cause of severe rhabdomyolysis.
- EIR is a very rare cause of acute kidney injury (AKI).
Purpose of the Study:
- To understand the epidemiology and risk factors for AKI in patients with EIR.
- To monitor the initial presentation, biochemical parameters, and clinical course of EIR patients who develop AKI.
Main Methods:
- Prospective observational study of 25 patients diagnosed with EIR.
- Monitoring of clinical presentation, biochemical markers, and outcomes.
- Comparison between patients with AKI (RAKI) and without AKI (NRAKI).
Main Results:
- Five out of 25 EIR patients developed AKI requiring renal replacement therapy (RRT).
- AKI patients showed male predominance, more systemic symptoms, oligo-anuria, compartment syndrome, and severe dehydration.
- Elevated creatinine kinase, myoglobin, impaired renal function, hyperuricemia, high D-dimer, and high PCV were associated with AKI.
- Delayed presentation and metabolic acidosis were linked to AKI development.
Conclusions:
- AKI in EIR patients is associated with specific clinical and laboratory findings.
- Early recognition and management are crucial for patients with EIR who develop AKI.
- AKI in EIR patients, though severe, showed no deterioration on 3-month follow-up after RRT.
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