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Related Experiment Videos

Majocchi's granuloma: current perspectives.

Hazal Boral1, Murat Durdu2, Macit Ilkit1

  • 1Division of Mycology, Department of Microbiology, Faculty of Medicine, University of Çukurova, Adana, Turkey.

Infection and Drug Resistance
|June 5, 2018
PubMed
Summary

Majocchi's granuloma, a rare fungal skin infection, is often caused by Trichophyton rubrum. Diagnosis relies on histopathology, and treatment involves topical and systemic antifungals like terbinafine.

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Area of Science:

  • Dermatology
  • Mycology
  • Infectious Diseases

Background:

  • Majocchi's granuloma (MG) is a rare fungal infection affecting the dermis.
  • Predominantly caused by dermatophytes, particularly Trichophyton rubrum (≥95% of cases).
  • Non-dermatophytic fungi like Aspergillus species can also cause MG.

Purpose of the Study:

  • To review current perspectives on Majocchi's granuloma.
  • To cover clinical characteristics, predisposing factors, diagnosis, and treatment.
  • To highlight recent trends in infection sites and common predisposing factors.

Main Methods:

  • Literature review of current perspectives on Majocchi's granuloma.
  • Analysis of clinical characteristics, predisposing factors, and diagnostic methods.
Keywords:
Trichophyton rubrumdermatomycosishistopathologyimmunosuppressionpredisposing factor

Related Experiment Videos

  • Evaluation of treatment strategies, including systemic and topical antifungal agents.

    • Main Results:

    • Facial involvement has become predominant in the last 5 years, shifting from the lower extremities.
    • Topical steroid use without proper examination is the most common predisposing factor (55%).
    • Histopathological examination, fungal culture, and molecular analyses are crucial for reliable diagnosis.

    Conclusions:

    • Majocchi's granuloma requires comprehensive treatment with both topical and systemic antifungal agents.
    • Systemic antifungal therapy should continue until complete lesion resolution.
    • Terbinafine is the preferred systemic agent due to its efficacy, safety, and favorable side effect profile.