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Activating Autophagy by Aerobic Exercise in Mice
Published on: February 3, 2017
Greater Colo-Rectal Activation Phenotype in Exercised mdx Mice
Marie Nearing1, James Novak2, Terence Partridge3
1Children's National Health System, Children's Research Institute, Center for Genetic Medicine Research, Washington DC, United States.
Introduction:
Duchenne Muscular Dystrophy is a genetic disease that is caused by a deficiency of dystrophin protein. Both Duchenne Muscular Dystrophy patients and dystrophic mice suffer from intestinal dysfunction.
Methods:
The present study arose from a chance observation of differences in fecal output of dystrophic vs. normal mice during 20-minutes of forced continuous treadmill exercise. Here, we report on the effects of exercise on fecal output in two different dystrophic mutants and their normal background control strains. All fecal materials evacuated during exercise were counted, dried and weighed.
Results:
Mice of both mutant dystrophic strains produced significantly more fecal material during the exercise bout than the relevant control strains.
Iscussion:
We propose that exercise--induced Colo--Rectal Activation Phenotype test could be used as a simple, highly sensitive, non-invasive biomarker to determine efficacy of dystrophin replacement therapies.
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