Related Experiment Video
Updated: Feb 9, 2026

Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal
Published on: September 12, 2025
Is a single day patient friendly methyl aminolevulinate photodynamic therapy illumination scheme for superficial
K P Nguyen1, G J Knuiman2, W A M Blokx2
1a Department of Dermatology , Radboud University Medical Center , Nijmegen , The Netherlands.
Background:
Topical methyl aminolevulinate photodynamic therapy (MAL-PDT) is highly effective for the treatment of superficial basal cell carcinoma (sBCC). Current European treatment protocol requires two hospital visits, which is costly and unpractical. The aim of this study was to evaluate the efficacy of fractionated MAL-PDT, using two light fractions at 3 and 4 h compared to illumination at 3 and 5 h after MAL-application.
Methods:
Thirty patients were randomized into two groups. The first group received illumination at 3 and 4 h (20 + 55 J/cm2) after MAL-application (3/4 group). In the other group, two light fractions were performed at 3 and 5 h (20 + 55 J/cm2) after MAL-application (3/5 group). The lesion response was evaluated at 3 and 12 months posttreatment.
Results:
In the 3/5 group, 70.0% showed a complete response (CR) at 3 months compared to 63.6% in the other group. At 12 months, 100% showed a CR in the 3/5 group compared to 80.0% in the other group. However, most failures/recurrences were eventually due to the presence of a more aggressive BCC subtype, mostly caused by sampling error of the primary punch biopsy.
Conclusion:
Single day protocol for MAL-PDT for sBCC is feasible and this study shows promising results.
Related Concept Videos
The Z-Scheme of Electron Transport in Photosynthesis
Pilot and Numeric Relaying
Trial and Error and Algorithm
Clinical Trials: Overview
Clinical Trials
There are four phases in a clinical trial. A phase one...
Random Error

