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Published on: September 14, 2017
Weakly-coordinating N-oxide and carbonyl groups for metal-catalyzed C-H activation: the case of A-ring
Eufrânio N da Silva Júnior1, Guilherme A M Jardim, Roberto S Gomes
1Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte, 31270-901, MG, Brazil. eufranio@ufmg.br.
Abstract:
Compounds featuring weakly-coordinating N-oxides or carbonyl groups, as for instance, quinoline N-oxide and quinonoid systems represent important structural scaffolds with potential biological activities. Due to their biological importance, significant efforts have been devoted to devise robust methods for their step-economical preparation. Among these approaches, the C-H activation strategy has emerged as a powerful, versatile and efficient tool in molecular sciences. This feature article summarizes recent key advances in transition-metal-catalyzed C-H functionalization for A-ring functionalization of heterocyclic and quinoidal compounds by challenging weakly-coordinating entities, published prior to May 2018.
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