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Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR
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Published on: July 22, 2012

Rotavirus infection in children presenting with acute gastroenteritis Ibadan, Nigeria

A H Fagbami, O A Johnson, T S David-West

    Transactions of the Royal Society of Tropical Medicine and Hygiene
    |January 1, 1985
    PubMed

    Insights

    Rotavirus infection was detected in 21% of Nigerian children with acute gastroenteritis. Infants aged 4-6 months showed the highest rotavirus infection rates, with no cases found in children over two years old.

    Area of Science:

    • Pediatrics
    • Virology
    • Infectious Diseases

    Background:

    • Acute gastroenteritis is a significant cause of childhood illness globally.
    • Rotavirus is a leading viral pathogen responsible for severe diarrheal disease in infants and young children.

    Purpose of the Study:

    • To determine the prevalence of rotavirus in children with acute gastroenteritis in Ibadan, Nigeria.
    • To investigate the age distribution of rotavirus infections in affected children.

    Main Methods:

    • Faecal samples were collected from 84 children with acute gastroenteritis and 28 controls.
    • Enzyme-linked immunosorbent assay (ELISA) was used to detect rotavirus antigens in faecal samples.

    Main Results:

    • Rotavirus was detected in 18 (21%) of the gastroenteritis cases, with no detection in the control group.
    • In-patients had a higher prevalence (25%) compared to out-patients (10%).
    • The highest infection rate (67%) was observed in children aged 4-6 months, followed by 7-12 months (33%), 0-3 months (13%), and 13-24 months (16%).

    Conclusions:

    • Rotavirus is a common cause of acute gastroenteritis in children in Ibadan, Nigeria.
    • Infants between 4 and 6 months are most vulnerable to rotavirus infection.
    • The findings highlight the need for rotavirus surveillance and potential intervention strategies in the region.

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