[Binary ethyleneimine as an inactivator of the foot-and-mouth disease virus]
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Updated: Aug 11, 2026

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
Published on: June 16, 2011
Abstract:
Experiments were carried out to inactivate F.M.D. viruses with the use of binary ethylene-imine. It was found that inactivation was optimal when the agent was used at the rate of 0.003 M for 18 hours at 26 degrees C. Its neutralization in the virus suspension was carried out with 3 mM sodium thiosulfate. The inactivated F.M.D. viruses retained their complement-fixing and immunogenic properties. Discussed are the advantages of using binary ethyleneimine as an inactivating agent as against other agents of the asiridine order.
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