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Related Concept Videos

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

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Related Experiment Video

Updated: Jun 29, 2026

RNAi-mediated Control of Aflatoxins in Peanut: Method to Analyze Mycotoxin Production and Transgene Expression in the Peanut/Aspergillus Pathosystem
09:44

RNAi-mediated Control of Aflatoxins in Peanut: Method to Analyze Mycotoxin Production and Transgene Expression in the Peanut/Aspergillus Pathosystem

Published on: December 21, 2015

[Experimentally induced aflatoxicosis in broilers].

L Borisova, M Duparinova, M Aleksandrov

    Veterinarno-Meditsinski Nauki
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Aflatoxicosis negatively impacts broiler chickens, causing significant changes in blood, reduced body weight, and liver damage. This study highlights the detrimental effects of aflatoxin contamination in poultry feed.

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    Published on: April 19, 2024

    Area of Science:

    • Veterinary Medicine
    • Animal Nutrition
    • Toxicology

    Background:

    • Aflatoxicosis is a significant concern in poultry production.
    • Aflatoxins are toxic secondary metabolites produced by fungi.
    • Contaminated feed poses a risk to animal health and food safety.

    Purpose of the Study:

    • To investigate the effects of dietary aflatoxin exposure on broiler chickens.
    • To evaluate haematological, biochemical, and pathological changes induced by aflatoxicosis.
    • To assess the impact on growth performance.

    Main Methods:

    • Two groups of broiler birds were fed diets containing 0.250 ppm and 0.600 ppm aflatoxin.
    • Haematological and biochemical indices were monitored.
    • Body weight, feed to gain ratio, and liver pathology were assessed.

    Main Results:

    • Significant alterations in haematological and biochemical parameters were observed.
    • A notable decrease in body weight gain was recorded.
    • Increased feed to gain ratio and pathological liver changes were evident.

    Conclusions:

    • Dietary aflatoxin exposure negatively affects broiler health and performance.
    • Aflatoxicosis leads to measurable physiological and pathological damage.
    • Feed contamination with aflatoxins requires careful management in poultry farming.