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[Angiotensin converting enzyme in lung diseases].

K Mayr, G Aspöck, K H Mayer

    Wiener Medizinische Wochenschrift (1946)
    |March 15, 1985
    PubMed
    Summary

    Serum angiotensin-converting enzyme (ACE) determination shows high reliability for distinguishing active from inactive sarcoidosis. However, its validity is reduced by elevated ACE in other pulmonary diseases.

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    Area of Science:

    • Biochemistry
    • Pulmonology
    • Clinical Chemistry

    Context:

    • Pulmonary diseases, particularly sarcoidosis, require accurate diagnostic methods.
    • Differential diagnosis between various lung conditions can be challenging.
    • Angiotensin-converting enzyme (ACE) activity is a potential biomarker.

    Purpose:

    • To evaluate the diagnostic validity of serum ACE determination for differentiating pulmonary diseases, especially sarcoidosis.
    • To assess the sensitivity and reliability of ACE activity measurements in patient cohorts.
    • To compare ACE activity with radiological staging and clinical disease activity.

    Summary:

    • Serum ACE activity was measured in 60 sarcoidosis patients and 80 with other pulmonary diseases.
    • While not correlating with X-ray staging, ACE levels reliably distinguished active from inactive sarcoidosis.
    • Elevated ACE in some non-sarcoidosis pulmonary conditions, particularly with hepatopathy, limits its diagnostic specificity.

    Impact:

    • ACE determination is a practical, sensitive, and accurate clinical-chemical method for selected patients.
    • It aids in diagnosing active sarcoidosis, potentially avoiding invasive procedures.
    • Monitoring ACE levels facilitates disease observation and therapy adjustment.

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