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Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
Published on: August 24, 2019
Circulating malondialdehyde concentrations in patients with stable chronic obstructive pulmonary disease: a
Panagiotis Paliogiannis1, Alessandro G Fois2,3, Salvatore Sotgia1
1Department of Biomedical Sciences - University of Sassari, Sassari, Italy.
Abstract:
The aim of this meta-analysis was to review the available evidence regarding the blood concentrations of the oxidative stress marker malondialdehyde (MDA) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. 14 studies were included in the meta-analysis (from inception to October 2017) with a total of 817 COPD patients and 530 healthy controls. Pooled MDA concentrations were significantly higher in patients with COPD than controls (standardized mean differences = 2.39 μmol/l, 95% CI: 1.50-3.28 μmol/l; p < 0.001). Our meta-analysis showed that the blood concentrations of MDA are consistently higher in patients with COPD when compared with healthy controls, suggesting an important role of lipid peroxidation, and thus oxidative stress, in the pathogenesis of COPD.
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