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Non-coding RNAs in virology: an RNA genomics approach
Christopher Isaac1, Trushar R Patel1,2,3, Athanasios Zovoilis1
1a Department of Chemistry and Biochemistry , Alberta RNA Research and Training Institute, University of Lethbridge , Lethbridge , Canada.
Biotechnology & Genetic Engineering Reviews
|June 6, 2018
Summary
Non-coding RNAs (ncRNAs) are crucial for cellular functions and survival. Viral and host ncRNAs significantly impact viral infections by regulating gene expression and host immunity, highlighting their importance in virology.
Area of Science:
- Molecular Biology
- Virology
- Genomics
Background:
- Non-coding RNAs (ncRNAs) are vital biomolecules regulating cellular functions and survival.
- Viral ncRNAs modulate viral gene expression and host immune responses.
- Host ncRNAs play a critical role in host-virus interactions.
Purpose of the Study:
- To discuss viral and mammalian ncRNAs involved in viral infections.
- To explore the role of ncRNAs in host-virus interactions.
- To highlight advancements in RNA genomics and next-generation sequencing for studying ncRNAs in virology.
Main Methods:
- Review of current literature on ncRNAs in viral infections.
- Analysis of sequencing technologies and bioinformatic approaches.
- Discussion of RNA genomics applications in virology.
Main Results:
- Identification of various viral and host ncRNAs associated with viral infections.
- Understanding the regulatory roles of ncRNAs in viral pathogenesis.
- Recognition of ncRNAs as key players in host-virus interactions.
Conclusions:
- ncRNAs are essential in viral infections, influencing viral gene expression and host immunity.
- RNA genomics and next-generation sequencing offer powerful tools for ncRNA research in virology.
- Further investigation into ncRNAs promises new insights into viral diseases and therapeutic strategies.
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