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Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
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Current Perspectives Regarding Stem Cell-based Therapy for Ischemic Stroke.

Kyeong-Ah Kwak1, Ho-Beom Kwon2, Joo Won Lee1

  • 1Department of Oral Anatomy, Seoul National University School of Dentistry and Dental Research Institute, Seoul, 101 Daehakro, Jongno-Gu, Seoul, 03080, Korea.

Current Pharmaceutical Design
|June 6, 2018
PubMed
Summary
This summary is machine-generated.

Stem cell therapy shows promise for stroke recovery by aiding brain repair. However, clinical trial results are currently inconclusive, requiring further research for effective application.

Keywords:
Strokeangiogenesiscell-based therapyclinical trialsimmunomodulationstem cells.

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Clinical Neurology

Background:

  • Stroke is a major global cause of death and disability.
  • Current treatments for stroke have limited therapeutic time windows.
  • Regenerative approaches, such as stem cell therapy, are needed.

Purpose of the Study:

  • To review stem cell research for ischemic stroke treatment.
  • To summarize clinical trial findings on stem cell therapy for stroke.
  • To discuss challenges hindering clinical application of stem cell therapy.

Main Methods:

  • Review of existing scientific literature on stem cell transplantation for ischemic stroke.
  • Analysis of experimental study findings.
  • Synopsis of conducted clinical trials and their outcomes.

Main Results:

  • Stem cell transplantation promotes functional recovery through neuroprotection, neurogenesis, angiogenesis, immunomodulation, and anti-inflammatory effects.
  • Experimental studies show promising results for stem cell therapy in stroke models.
  • Clinical trial efficacy data remains inconclusive.

Conclusions:

  • Stem cell therapy holds potential for treating ischemic stroke.
  • Further research is necessary to overcome hurdles for successful clinical application.
  • Addressing current challenges is crucial for realizing the therapeutic benefits of stem cells in stroke patients.