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Related Concept Videos

Induced-fit Model01:13

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Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Induced Pluripotent Stem Cells01:06

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Induced Electric Dipoles01:28

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A permanent electric dipole orients itself along an external electric field. This rotation can be quantified by defining the potential energy because the external torque does work in rotating it. Then, the potential energy is minimum at the parallel configuration and maximum at the antiparallel configuration. While the former is a stable equilibrium, the latter is an unstable equilibrium.
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Induced Electric Fields01:23

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The fact that emfs are induced in circuits implies that work is being done on the conduction electrons in the wires. What can possibly be the source of this work? We know that it’s neither a battery nor a magnetic field, as a battery does not have to be present in a circuit where current is induced, and magnetic fields never do any work on moving charges. The source of the work is in fact an electric field that is induced in the wires. For example, if a stationary conductor is placed in a...
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Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).
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Related Experiment Video

Updated: Feb 9, 2026

Real-Time Imaging of CCL5-Induced Migration of Periosteal Skeletal Stem Cells in Mice
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Voriconazole-induced Severe Periostitis Deformans.

Shakir Hussain1

  • 1Department of Oncology, The Royal Orthopaedic Hospital Birmingham, UK.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|June 6, 2018
PubMed
Summary

Voriconazole can cause periostitis deformans, a rare bone condition, even in patients not on immunosuppressants. This case highlights voriconazole

Area of Science:

  • Medical Imaging
  • Pharmacology
  • Orthopedics

Background:

  • Periostitis deformans is an uncommon skeletal condition causing bone pain and swelling.
  • Voriconazole-induced periostitis is typically observed in immunosuppressed organ transplant recipients.

Observation:

  • A patient developed widespread periostitis deformans secondary to voriconazole treatment.
  • The patient was not on immunosuppressant therapy but was being treated for skull base aspergillus osteomyelitis.

Findings:

  • This case demonstrates voriconazole's potential for severe adverse effects beyond typical patient profiles.
  • Radiological features of periostitis deformans can mimic bone tumors, complicating diagnosis.

Implications:

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  • Highlights the need for increased awareness of voriconazole's adverse effects in non-transplant patients.
  • Aims to improve diagnostic strategies and streamline investigations for orthopedic surgeons and radiologists.
  • Emphasizes the importance of considering drug-induced conditions in differential diagnoses.