Related Experiment Videos
[Effect of methadone administration on MHV-3 virus-induced experimental hepatitis in the mouse]
Bollettino Della Societa Italiana Di Biologia Sperimentale
|February 28, 1985
Abstract:
Mice treated with 15 mg/Kg/day methadone and infected with MHV-3 virus after 7 days did not show increased susceptibility to MHV-3 virus infection, did not develop more serious forms of hepatitis and not mortality did not increase with respect to the controls. Drug administration was continued for the duration of the experiment.
Insights
Methadone treatment did not increase susceptibility or severity of hepatitis in mice infected with the MHV-3 virus. Mortality rates remained unchanged compared to control groups in this study.
Area of Science:
- Virology
- Immunology
- Pharmacology
Context:
- Hepatitis is an inflammation of the liver.
- Murine hepatitis virus (MHV-3) is a common cause of hepatitis in mice.
- Methadone is an opioid medication used to treat pain and opioid use disorder.
Purpose:
- To investigate the effect of methadone on MHV-3 infection susceptibility and severity in mice.
Summary:
- Mice treated with methadone (15 mg/Kg/day) and subsequently infected with MHV-3 did not exhibit increased susceptibility to the virus.
- No more severe forms of hepatitis or increased mortality were observed in the methadone-treated group compared to controls.
- Methadone administration was maintained throughout the experimental period.
Impact:
- This study suggests that methadone does not exacerbate MHV-3 induced hepatitis in a murine model.
- Findings may inform clinical decisions regarding methadone use in patients with or at risk for viral hepatitis.