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Related Experiment Video

Updated: Feb 9, 2026

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

VDJServer: A Cloud-Based Analysis Portal and Data Commons for Immune Repertoire Sequences and Rearrangements.

Scott Christley¹, Walter Scarborough², Eddie Salinas¹

¹Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States.

Frontiers in Immunology

|June 6, 2018

Summary

VDJServer offers a cloud-based platform for analyzing immune repertoire sequencing data, simplifying complex bioinformatics workflows for researchers. This accessible tool aids in understanding adaptive immunity in health and disease.

Keywords:

B-cell receptor Rep-seq T cell receptor bioinformatics cloud computing immune repertoire

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Area of Science:

Immunology
Bioinformatics
Computational Biology

Background:

Immune repertoire sequencing generates complex data crucial for understanding adaptive immunity in health and disease.
Specialized bioinformatics methods and software tools are essential for analyzing these large datasets.

Purpose of the Study:

To introduce VDJServer, a cloud-based portal for comprehensive immune repertoire sequence data analysis.
To provide a user-friendly, accessible platform for researchers without requiring programming expertise.

Main Methods:

VDJServer offers a suite of tools for preprocessing, quality control, V(D)J gene assignment, and repertoire comparison.
The platform features a graphical user interface accessible via web browser, with sophisticated visualization tools.
It includes data management, analysis workflows, and computational provenance tracking.

Main Results:

VDJServer supports complete analysis workflows for human and mouse T-cell and B-cell receptor repertoire sequencing data.
The platform enables analysis of large immune repertoire sequencing projects without programming or software installation.
It facilitates data sharing through a public data commons and private user sharing.

Conclusions:

VDJServer is a free, open-source, web-accessible cloud platform simplifying immune repertoire data analysis.
Its integrated tools and user-friendly interface empower immunologists, clinicians, and bioinformaticians.
The platform enhances research in areas like cancer immunology and autoimmunity by making complex data analysis accessible.