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Association Between Disease Severity and Calcium Concentration in Critically Ill Patients Admitted to Intensive Care

Sarvin Sanaie1, Ata Mahmoodpoor2, Hadi Hamishehkar3

  • 1Tuberculosis and lung disease research center, Tabriz University of Medical Sciences, Tabriz, Iran.

Anesthesiology and Pain Medicine
|June 6, 2018
PubMed

Insights

Hypocalcemia in intensive care unit (ICU) patients is linked to disease severity. Ionized calcium levels strongly predict severity, making it crucial for ICU patient assessment.

Area of Science:

  • Critical Care Medicine
  • Clinical Chemistry
  • Electrolyte Balance

Background:

  • Hypocalcemia is frequent in critically ill patients.
  • The clinical significance of hypocalcemia in early ICU stays is unclear.
  • Calcium assessment is vital for these patients.

Purpose of the Study:

  • To evaluate the relationship between various calcium concentrations (total, ionized, corrected) and disease severity in ICU patients.

Main Methods:

  • A prospective trial involving 100 ICU patients.
  • Measured total, corrected, and ionized calcium levels.
  • Assessed the relationship with APACHE score and disease severity.

Main Results:

  • Strong inverse correlation between disease severity and ionized calcium (P < 0.001, r = -0.697).
  • Medium inverse correlation between disease severity and total calcium (P < 0.001, r = -0.368).
  • Weak direct correlation between disease severity and corrected calcium (P = 0.02, r = 0.232).

Conclusions:

  • Ionized calcium and total calcium correlate significantly.
  • Corrected calcium does not correlate significantly with ionized calcium.
  • Hypocalcemia predicts disease severity and mortality in ICU patients.
  • Recommends measuring ionized calcium in ICU admissions.
Abstract

Keywords:
Critically Ill PatientsDisease SeverityHospital MortalitySerum Calcium

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