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Mycobacterium tuberculosis: An Adaptable Pathogen Associated With Multiple Human Diseases
Qiyao Chai1,2, Yong Zhang1,2, Cui Hua Liu1,2
1CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Frontiers in Cellular and Infection Microbiology
|June 6, 2018
Summary
Mycobacterium tuberculosis (TB) evades host immunity and establishes latency within granulomas. Understanding its interaction with host diseases and the microbiome is key to developing better TB treatments.
Area of Science:
- Infectious Diseases
- Immunology
- Microbiology
Background:
- Mycobacterium tuberculosis (TB) is a successful pathogen causing latent infections within host granulomas.
- M. tuberculosis manipulates host immunity and can reactivate when immunity is compromised.
- Emerging evidence links M. tuberculosis to other diseases and the human microbiome.
Purpose of the Study:
- To review the adaptive survival strategies of M. tuberculosis within the host.
- To provide an overview of regulatory mechanisms in M. tuberculosis infection and associated human diseases.
- To highlight the reciprocal interactions between M. tuberculosis and the human microbiome.
Main Methods:
- Literature review of adaptive survival mechanisms.
- Analysis of regulatory pathways in host-pathogen interactions.
- Examination of M. tuberculosis's role in diverse human diseases and microbiome interplay.
Main Results:
- M. tuberculosis employs effector proteins to evade immune responses during latency.
- Granuloma formation is a key niche for M. tuberculosis survival and potential reactivation.
- M. tuberculosis infection influences comorbidities like autoimmune and metabolic diseases.
Conclusions:
- Understanding M. tuberculosis's immune regulation is crucial for TB control.
- Targeting host-pathogen interactions may alleviate TB and associated comorbidities.
- Further research into M. tuberculosis and microbiome interplay is warranted for comprehensive health strategies.
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