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Interventional Cardio-Oncology: Adding a New Dimension to the Cardio-Oncology Field
Victor Y Liu1, Ali M Agha1, Juan Lopez-Mattei2,3
1Department of Internal Medicine, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, United States.
Insights
Managing cardiovascular disease in active cancer patients requires special care due to comorbidities and cancer treatments. This review discusses safety measures and intravascular imaging for high-risk percutaneous coronary intervention (PCI) in these patients.
Area of Science:
- Cardiology
- Oncology
- Interventional Cardiology
Background:
- Cardiovascular disease management in active cancer patients poses unique interventional cardiology challenges.
- Cancer patients frequently have comorbidities like thrombocytopenia and coagulation disorders, increasing vascular access complication risks.
- Anticancer therapies can induce vascular endothelial and myocardial injury.
Purpose of the Study:
- To review safety measures for invasive cardiovascular procedures in cancer patients.
- To discuss the role of intravascular imaging in managing high-risk cancer patients undergoing percutaneous coronary intervention (PCI).
- To address the lack of data from clinical trials and registries for this patient population.
Main Methods:
- Review of existing literature on managing cardiovascular disease in cancer patients.
- Discussion of safety protocols applicable before and during invasive cardiovascular procedures.
- Exploration of the utility of intravascular imaging techniques.
Main Results:
- Cancer patients present complex challenges due to comorbidities and treatment side effects.
- Standard percutaneous coronary intervention (PCI) protocols may not be optimal for cancer patients.
- Safety measures and advanced imaging are crucial for managing these high-risk individuals.
Conclusions:
- Optimizing cardiovascular care for cancer patients requires tailored approaches.
- Implementing specific safety measures and utilizing intravascular imaging can improve outcomes.
- Further research is needed to establish evidence-based guidelines for PCI in cancer patients.
Abstract:
The management of cardiovascular disease in patients with active cancer presents a unique challenge in interventional cardiology. Cancer patients often suffer from significant comorbidities such as thrombocytopenia and coagulopathic and/or hypercoagulable states, which complicates invasive evaluation and can specifically be associated with an increased risk for vascular access complications. Furthermore, anticancer therapies cause injury to the vascular endothelium as well as the myocardium. Meanwhile, improvements in diagnosis and treatment of various cancers have contributed to an increase in overall survival rates in cancer patients. Proper management of this patient population is unclear, as cancer patients are largely excluded from randomized clinical trials on percutaneous coronary intervention (PCI) and national PCI registries. In this review, we will discuss the role of different safety measures that can be applied prior to and during these invasive cardiovascular procedures as well as the role of intravascular imaging techniques in managing these high risk patients.
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