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Transvaginal Mesh Insertion in the Ovine Model
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Reference Ranges for Transvaginal Examined Fossa Posterior Structures in Fetuses from 45 to 84 mm Crown-Rump Length.

Reinhard Altmann1, Christian Specht2, Iris Scharnreitner1

  • 1Department of Prenatal Medicine, Kepler University Hospital, Linz, Austria.

Gynecologic and Obstetric Investigation
|June 6, 2018
PubMed
Summary

This study establishes reference values for fetal posterior fossa structures using crown-rump length (CRL) measurements. These findings aid in the early detection of fetal malformations during pregnancy.

Keywords:
1 st Trimester screeningFetal fossa posteriorHypoplasia/Aplastia of the vermisReference rangesTransvaginal 3D ultrasound

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Area of Science:

  • Fetal Medicine
  • Medical Imaging
  • Developmental Biology

Background:

  • Accurate fetal anatomical measurements are crucial for diagnosing developmental abnormalities.
  • The posterior fossa is a key region for assessing fetal neurological development.

Purpose of the Study:

  • To establish normative reference values for posterior fossa structures in fetuses.
  • To correlate these measurements with crown-rump length (CRL) in early gestation.

Main Methods:

  • A prospective, cross-sectional study of 216 fetuses with CRL between 45 and 84 mm.
  • 3D ultrasound was used to measure the vermis (VE), posterior membranous area (PMA), medulla-oblongata-pons angle (MOPA), medulla oblongata (MO), pons (PO), and Blake's pouch (BP).
  • Regression analysis was performed to derive reference ranges based on CRL.

Main Results:

  • Curvilinear and linear regression models were established for CRL correlations with PO, MO, VE, PMA, BP, and MOPA.
  • Specific regression equations and R-squared values are provided for each measured structure.
  • Intra- and interobserver repeatability were assessed in a subset of fetuses.

Conclusions:

  • Reference values for fetal posterior fossa structures (45-84 mm CRL) have been established.
  • These normative data can assist in the early diagnosis of fetal malformations.
  • The study provides valuable tools for routine obstetric ultrasound assessments.