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[Research advancement in related genes of Ménière's disease]
Abstract:
Starting from rational bases for a genetic approach to Ménière's disease (MD), we explored the numerous reports published in literature and summarized the recent advances in understanding of the genetic fundaments of the disease. The research advances related to the genetic fundaments of MD were reviewed. The incidence of MD presents as familial clustering and hasdifference in geographical and racial, no certain gene associated with MD was found. At present, studies concentrate on those genes, such as human leukocyte antigen (HLA), DFNA9, chromosome 12, macrophage migration inhibitory factor(MIF), KCNE, and heat shock protein (HSP). However, there have much arguments in diagnose, classify and pathophysiology of MD, resulting in different conclusion and prospect. The characteristics of MD strongly suggest a certain role for genetic factors in the development of MD, no convincing evidence for an association with any gene exists. To make a more strict quality control and continue explore the genetic factors of MD, will be meaningful in the future.
Insights
Genetic factors likely contribute to Ménière
Area of Science:
- Otolaryngology, Genetics, Neurology
Background:
- Ménière's disease (MD) exhibits familial clustering, suggesting a genetic component.
- Previous research has investigated various genes, including HLA, DFNA9, and MIF, but no definitive association has been established.
- Diagnostic and pathophysiological heterogeneity complicates genetic studies of MD.
Purpose of the Study:
- To review and summarize current understanding of the genetic underpinnings of Ménière's disease.
- To identify key genes and genetic factors implicated in MD pathogenesis.
- To highlight challenges and future directions in MD genetic research.
Main Methods:
- Comprehensive literature review of studies on Ménière's disease genetics.
- Analysis of reported genetic associations and candidate genes.
- Synthesis of findings regarding the role of genetic factors in MD.
Main Results:
- Despite familial clustering and geographical variations, no specific gene has been conclusively linked to Ménière's disease.
- Candidate genes such as human leukocyte antigen (HLA), DFNA9, chromosome 12, macrophage migration inhibitory factor (MIF), KCNE, and heat shock protein (HSP) have been explored.
- Inconsistent diagnostic criteria and understanding of MD pathophysiology contribute to conflicting research outcomes.
Conclusions:
- While genetic factors are strongly suspected in Ménière's disease development, conclusive evidence linking specific genes is lacking.
- Further research with stringent quality control is necessary to elucidate the genetic etiology of MD.
- Future studies should focus on refining diagnostic standards and exploring novel genetic associations.
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