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The Lung and Esophagus: Developmental and Regenerative Overlap
Edward E Morrisey1, Anil K Rustgi2
1Division of Cardiovascular Medicine, Center for Pulmonary Biology, Cardiovascular Institute, Institute for Regenerative Medicine, Abramson Cancer Center, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.
Trends in Cell Biology
|June 7, 2018
Summary
Lung and esophageal development share common regenerative properties after separation. These insights into tissue organogenesis offer perspectives on squamous cell cancers and adenocarcinomas.
Area of Science:
- Developmental biology
- Regenerative medicine
- Oncology
Background:
- Lung and esophageal organogenesis involve complex signaling pathways and transcriptional factors.
- Epithelial proliferation and differentiation programs in the lung and esophagus share commonalities.
- These shared properties may contribute to adaptive responses to injury and regeneration.
Purpose of the Study:
- To explore the shared properties of lung and esophageal epithelial programs.
- To understand the implications of these shared properties for tissue regeneration.
- To provide perspectives on squamous cell cancers and adenocarcinomas in both tissues.
Main Methods:
- Comparative analysis of developmental pathways.
- Investigation of epithelial cell proliferation and differentiation.
- Examination of regenerative responses to injury.
Main Results:
- Identified shared characteristics in epithelial proliferation and differentiation between lung and esophagus post-separation.
- Highlighted the potential of these shared programs to drive adaptive regeneration.
- Established a link between organogenesis/regeneration and cancer development.
Conclusions:
- The commonalities in lung and esophageal epithelial programs are crucial for regeneration.
- Understanding these processes offers insights into squamous cell carcinoma and adenocarcinoma.
- This research bridges developmental biology, regeneration, and cancer research.
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