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Analyzing Long-Term Electrocardiography Recordings to Detect Arrhythmias in Mice

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Published on: May 23, 2021

Mesalamine Associated Bradycardia.

Michael Krzyzak¹, Anupam Gupta¹, Evgeny Antonov²

¹Department of Medicine, Staten Island University Hospital, Northwell Health, Staten Island, USA.

|June 7, 2018

Summary

This summary is machine-generated.

Mesalamine, a common ulcerative colitis treatment, can cause severe sinus bradycardia. This rare side effect involves a dangerously slow heart rate. Prompt recognition and discontinuation of mesalamine are crucial for recovery.

Keywords:

bradycardia drug side effects ulcerative colitis

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Area of Science:

Gastroenterology
Cardiology
Pharmacology

Background:

Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
Mesalamine is a first-line treatment for mild to moderate UC flares.
Adverse cardiovascular events are rarely associated with mesalamine therapy.

Observation:

A 38-year-old female with an acute UC flare was treated with prednisone and mesalamine.
Within 24 hours of initiating mesalamine, she developed severe sinus bradycardia.
Her heart rate normalized within five days after discontinuing mesalamine.

Findings:

This case represents the third documented instance of severe sinus bradycardia linked to mesalamine use.
Mesalamine-induced bradycardia is a rare but significant adverse drug reaction.
The temporal relationship suggests a causal link between mesalamine and the cardiac event.

Implications:

Clinicians should be aware of the potential for mesalamine to cause bradycardia in ulcerative colitis patients.
Monitoring heart rate in patients initiating mesalamine may be warranted.
Further investigation into the mechanism of mesalamine-induced cardiac effects is needed.