Epigenetic Modifications Linked to T2D, the Heritability Gap, and Potential Therapeutic Targets
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Updated: Feb 9, 2026

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
Published on: May 5, 2023
Monica Szabó1,2, Beáta Máté3, Katalin Csép4
1Department of Internal Medicine, University of Medicine and Pharmacy of Tîrgu Mureș, 38 Gheorghe Marinescu Street, 540139, Tîrgu Mureș, Romania. szabo.monika@umftgm.ro.
Abstract:
With the pandemic of type 2 diabetes (T2D), there is an ever-increasing need to fully understand the underlying mechanisms of the disease. Type 2 diabetes shows a high heritability risk (25-80%); however, genes account only for 10% of this risk. From all the risk factors for diabetes, epigenetic mechanisms have the highest statistical scoring in explaining the disease. A multitude of organ-specific epigenomic changes have been linked to type 2 diabetes. Nutritional influences, mainly in the early life, physical activity level, environmental toxins act as epigenetic factors and the recognized epigenetic changes can represent a therapeutical target, new drugs being currently in development for this application. Our current review focuses on the most common epigenetic modifications linked to type 2 diabetes or insulin resistance, the potentially emerging epigenetic-related interventions and pharmacoepigenetic knowledge.
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