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PSMA Theranostics: Current Status and Future Directions.

Kambiz Rahbar1, Ali Afshar-Oromieh2, Hossein Jadvar3

  • 11 Department of Nuclear Medicine, University Hospital Muenster, Muenster, Germany.

Molecular Imaging
|June 7, 2018
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Summary

Prostate-specific membrane antigen (PSMA) theranostics show promise for prostate cancer. Radiolabeled PSMA ligands offer effective imaging and targeted radionuclide therapy with good response rates and low toxicity.

Keywords:
177Lu-PSMAPSMAmCRPCprostate cancerradioligand therapy

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiopharmaceutical Therapy

Background:

  • Prostate-specific membrane antigen (PSMA) is a key biomarker in prostate cancer.
  • PSMA-targeted diagnostics and therapeutics (theranostics) are emerging for prostate cancer management.

Purpose of the Study:

  • To review the current applications of radiolabeled PSMA ligands in diagnostics and therapy.
  • To propose guidelines for patient selection and treatment protocols for PSMA-based radioligand therapy (RLT).

Main Methods:

  • Review of current literature on PSMA theranostics.
  • Discussion of diagnostic imaging and therapeutic applications of radiolabeled PSMA ligands.
  • Analysis of patient selection criteria and RLT protocols.

Main Results:

  • 177Lu-labeled PSMA ligands demonstrate encouraging response rates in metastatic castration-resistant prostate cancer.
  • PSMA-based radioligand therapy exhibits a favorable toxicity profile.
  • PSMA theranostics offer a dual approach for diagnosis and treatment.

Conclusions:

  • Radiolabeled PSMA ligands are a valuable tool for prostate cancer theranostics.
  • Standardized protocols for patient selection and RLT conduct are needed.
  • Further research into PSMA theranostics presents opportunities for improved prostate cancer care.