Catalytic Transformations of Functionalized Cyclic Organic Carbonates.
Wusheng Guo1, José Enrique Gómez2,3, Àlex Cristòfol2,3
1Center for Organic Chemistry, Frontier Institute of Science and Technology (FIST), Xi'an Jiaotong University, Xi'an, 710045, China.
Angewandte Chemie (International Ed. in English)
|June 7, 2018
Summary
Cyclic organic carbonates are versatile building blocks for creating complex molecules through catalytic ring-opening and decarboxylative reactions. Transition-metal catalysis enables new stereo- and enantioselective bond formations, expanding synthetic possibilities.
Area of Science:
- Organic Chemistry
- Catalysis
- Heterocyclic Chemistry
Background:
- Cyclic organic carbonates are valuable heterocyclic substrates.
- Their functionalization enables diverse chemical transformations.
- Transition-metal catalysis is increasingly important in organic synthesis.
Purpose of the Study:
- To review the synthetic utility of functionalized cyclic organic carbonates and related heterocycles.
- To highlight their role in catalytic ring-opening and decarboxylative reactions.
- To discuss the mechanistic pathways involved in these transformations.
Main Methods:
- Literature review of transition-metal-mediated conversions.
- Focus on stereo- and enantioselective C-N, C-O, C-C, C-S, and C-B bond formations.
- Analysis of mechanistic manifolds in heterocyclic conversions.
Main Results:
- Demonstration of cyclic carbonates as versatile substrates.
- Advancement in stereo- and enantioselective bond formation reactions.
- Rejuvenation of transition-metal-mediated approaches for complex molecule synthesis.
Conclusions:
- Cyclic organic carbonates offer significant synthetic potential.
- Transition-metal catalysis provides powerful tools for their conversion.
- These methods facilitate the development of novel synthetic strategies.
Keywords:
cyclic organic carbonatesdecarboxylative couplingsheterocycleshomogeneous catalysistransition-metal catalysisMore Related Videos
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